Pharmacokinetic Characteristics and Antitumor Activity of the N-Succinyl-chitosan-Mitomycin C Conjugate and the Carboxymethyl-chitin-Mitomycin C Conjugate.
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Cellular interaction and in vitro antitumor activity of mitomycin C-dextran conjugate.
Cellular interaction and in vitro antitumor activity of a polymeric prodrug of mitomycin C (MMC), mitomycin C-dextran conjugate (MMC-D), were studied in relation to its physicochemical characteristics. MMC-D with cationic and anionic charges were examined. The cationic MMC-D was synthesized using a spacer, epsilon-aminocaproic acid and dextrans with molecular weights of 10,000, 70,000, or 500,0...
متن کاملDisposition Characteristics of Mitomycin C-Dextran Conjugate in Normal and Tumor-bearing Muscles of Rabbits1
Disposition characteristics of the macromolecular prodrug of mito mycin C (MM< '), mitomycin C-dextran conjugate (MMC-D), in normal and tumor (VX2 carcinoma)-bearing rabbit thigh muscles were studied using the in situ vascular perfusion technique. Three types of cationic MMC-D (MMC-D.,,) and two types of anionic MMC-D (MMC-D.,,) with different carrier molecular weights were used. After bolus ar...
متن کاملDisposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits.
Disposition characteristics of the macromolecular prodrug of mitomycin C (MMC), mitomycin C-dextran conjugate (MMC-D), in normal and tumor (VX2 carcinoma)-bearing rabbit thigh muscles were studied using the in situ vascular perfusion technique. Three types of cationic MMC-D (MMC-Dcat) and two types of anionic MMC-D (MMC-Dan) with different carrier molecular weights were used. After bolus arteri...
متن کامل[Mitomycin C and excimer laser].
Mitomycin C is an antimetabolite agent that blocks DNA and RNA replication and protein synthesis. It has been used in several ophthalmologic areas, and recently as a modulator of corneal wound healing in excimer laser surgeries. A single application of mitomycin C during surface corneal photoablative surgery seems a safe and efficient therapeutic option for eyes with corneal opacity and/or as p...
متن کاملCytogenetic study on genotoxicity of antitumor-antibiotic Mitomycin C
Mitomycin C (MMC) is antitumor-antibiotic, currently in use for treatment of various solid tumors. The effect of different dosages of MMC was tested in human lymphocyte culture after exposure for different duration. The exposure of 0.05μg/ml MMC for 24 hours was not sufficient to induce mitotic inhibition and chromosomal aberrations. The cells exposed to concentration 2.0μg/ml and above for las...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1993
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.16.48